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KMID : 0861020140290030035
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Korea Journal of Herbology
2014 Volume.29 No. 3 p.35 ~ p.42
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A quantitative analysis of marker compounds in single herb extracts by the standard of KHP
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Park Sang-Jun
Kim So-Hyung
Kim Kyung-Suk
Kim Hyo-Seon
Lee A-Young
Kim Ho-Kyoung
Kim Yun-Kyung
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Abstract
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Objectives : Since single extract powders was released at 1987, the insurance fee has not been changed, but the price of raw material has been increasing. According to this, Pharmaceutical company couldn`t invest on quality of the product, so, the quality of single extracts went down and lost the consumer`s trust. We checked the contents of marker ingredients in single extract thereby to recover the reliability of insurance-covered herbal preparations.
Methods : we bought total twelve products of eight different single extracts of two main pharmaceutical companies among total 65 kinds of single extract powder stipulated in KHP (The Korean Herbal Pharmacopoeia) monograph Ⅲ at Jan. 2013. Assays of selected single extract powders are performed by KHP regulation. And we surveyed price fluctuation of relevant herb raw materials from 2005 to 2012.
Results : Among twelve products, eight single extract powders were suitable by the KHP regulation. But four products didn`t reach the content amount of KHP. Marker contents in the single extracts product of Pueraria Root, Licorice, Peony root and Scutellaria Root of A company were 70%, 1%, 23.7% and 75.1%, respectively.
Conclusions : We can acertain whether there`s a quality problem in the insurance-covered single extract powders. But, A company is no longer producing these improper single extract powders. As a medicine, single extract powders needs to be strictly quality controlled by the company, and regularly monitored by the KFDA.
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KEYWORD
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Herbal medicinal preparations, National Health Insurance, Single extract powder, Marker compound
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